منابع مشابه
MAPK Pathway in Skeletal Muscle Diseases
Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that functions in a wide range of physiological and pathophysiological cellular events including cell proliferation, differentiation, apoptosis, migration, inflammation, metabolic disorders and diseases. In skeletal muscle, it plays an essential role in muscle fiber specialization, muscle mass maintenance, damage i...
متن کاملExercise Stimulates Pgc-1 Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway*
Peroxisome proliferator-activated receptor co-activator 1 (PGC-1 ) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that activation of the p38 mitogen-activated protein kinase (MAPK) pathway in response to increased muscle activity stimulated Pgc-1 gene transcription as part of the mechanisms for skeletal muscle adaptation. Here we report that a sin...
متن کاملExercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that activation of the p38 mitogen-activated protein kinase (MAPK) pathway in response to increased muscle activity stimulated Pgc-1alpha gene transcription as part of the mechanisms for skeletal muscle adaptation. Here ...
متن کاملSerum alanine aminotransferase in skeletal muscle diseases.
Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibi...
متن کاملExercise, MAPK, and NF- B signaling in skeletal muscle
Kramer HF, Goodyear LJ. Exercise, MAPK, and NFB signaling in skeletal muscle. J Appl Physiol 103: 388–395, 2007. doi:10.1152/japplphysiol.00085.2007.— Mitogen-activated protein kinases (MAPKs) and NFB are two major regulators of gene transcription and metabolism in response to oxidative, energetic, and mechanical stress in skeletal muscle. Chronic activation of these signaling pathways has been...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science and Animal Husbandry
سال: 2013
ISSN: 2348-9790
DOI: 10.15744/2348-9790.1.e104